you have to feed "in order to keep going as a vampire" - this might suggest a contrast with Oblivion, where feeding resulted in you losing your vampire traits and if you wanted to remain powerful as a vampire, you couldn't feed.
Romance/Marriage "you put on an amulet and it shows the other characters in the game you're interested"
Matt's comment about spouses adventuring seems to indicate that every spouse can be asked to adventure with you, even if their day job is baking bread, for example.
spouses cook a special meal for the PC once per day
According to Matt, the devs haven't figured out what they're gonna do with DLC yet, but they are excited about adding new content and "new features"
when asked if there is a location where you can change your appearance like Pinkerton lab in FO3 - Matt's response: "might be one of those features we add later"
Dwemer Centurion pic on the loading screen - Centurions are considered very high level creatures, lots of varieties of Centurions in the game
Throat of the World - climbing the steps is "a good trek" lots of nice views along the way.
spells that "might do something similar" to hail
close to 100 spells (previously we were told there were 85+)
all spell effects are "incredibly unique, with unique perks for each [magic] skill"
you can summon Dremora and beings from Oblivion
crime system is a little easier on the player, if you steal food, etc., it's up to each NPC, depending on how much they like you, to decide what they will allow you to get away with.
When asked about Daedric quests, Matt indicated there is "involvement with “The Prince” and challenges along the way that should satisfy the Daedric fans."
Hand to hand is lethal, you can kill using your fists. (It has been previously mentioned that there are specific non-lethal "tavern brawls," so I assume these take place in specific environments, like taverns)
when you complete the faction quest lines for The Companions, College of Winterhold, Thieves'Guild or Dark Brotherhood, you automatically become the leader of the faction.
However, "previously you were done with an area of play once you become a Guildmaster, but in Skyrim you will be able to continue with specific guild gameplay after becoming the head of a guild."
Dragons will not be using every shout available in the game. " It is possible to assume that every shout has been used in the past by a dragon, however during the game, the dragons only use certain shouts that make sense for the situations. They are incredibly intelligent AI creatures that use what is appropriate. Some shouts don’t make sense for dragons to use in this game and won’t be used."
You start out being able to summon only one creature, but after you learn a particular perk in the Conjuration skill tree, you can summon two.
You cannot dye armor and clothing.
You cannot enchant arrows, but you can enchant bows
No magic finishing moves
Hundreds of different NPCs you can marry, if they want to marry you.
Many "Lover's bonuses" available
Spouse can cook for the PC once per day increasing your health.
You can delgate tasks and send your followers to do things for you such as attack, collect food, buy weapons and more.
No "bow chicka wow-wow" animations
No bedrolls
Other NPCs may also interject a discussion, which gives a greater sense of dynamism and drama to the dialog.